The Department of Cell and Developmental Biology at the Würzburg Biocenter offers

5 PhD-student positions

We study molecular, cellular and physical aspects of African Sleeping Sickness, a prototypic neglected tropical disease of poverty. Transmitted by the infamous tsetse fly, trypanosomes do not only infect humans, but also kill cattle, which poses an enormous economic burden to Sub-Saharan Africa. Besides studying the transmission and pathogenesis of trypanosomes, we employ an exceptionally broad spectrum of techniques to exploit trypanosomes as versatile cell biological model system.

A recent Master’s degree in molecular or cellular biology, biophysics or a related field.
Strong analytical skills, a problem-solving and highly motivated attitude.
Creative and innovative thinking and a team-oriented mind-set.

Position 1 Characterisation of a novel mRNA decapping enzyme, with biochemistry and leading  
edge RNA biology techniques such as intra-molecular multicolour smRNA FISH (Susanne Kramer)

Position 2 Membrane biophysics of African trypanosomes, including implementation of
3D single-molecule dynamics, live-cell super-resolution, and image processing (Susanne Fenz)

Position 3 Control of membrane traffic in African trypanosomes, using high-end quantitative    
microscopy (CLEM, SIM, dSTORM), genome editing and structural biology (Markus Engstler)

Position 4 Tsetse-transmission of African trypanosomes, with special emphasis on signalling,
chemo- and mechanotaxis (Markus Engstler)

Position 5 Correlation of membrane dynamics and cell motility, using microfluidics, single
particle tracking and cryo-EM (Markus Engstler)

How to apply:
Please send your application (motivation letter, CV, names of two referees and transcripts in one PDF) citing “5PhD” in the subject line by email to Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann. . Evaluation of candidates will begin immediately, and continue until the positions are filled.

Susanne Kramer    -    Susanne Fenz    -    Markus Engstler                                                      February 14th, 2018





A PhD position is available at the Institute of Animal Pathology, University of Bern to join our molecular parasitology group.

PhD Position - Molecular Parasitology

Our parasitology group ( works on the host pathogen interaction of intracellular parasites. We study the mechanisms of host cell transformation by apicomplexan parasites. As a main model organism, we use the cattle pathogen Theileria annulata. Theileria is widely known to transform the host cell by interference with signaling pathways, turning cells in an epigenetic cancer cell-like state.

In the scope of this project, we intend to develop a variety of advanced biochemical, cellular, proteomic and genetic approaches to better understand the host cell transformation caused by the parasite. There is a huge quantity of detailed information about altered host signaling pathways that mediate the phenotypic changes observed in Theileria-infected cells. Parasite effectors involved in this transformation are, however, largely unknown. We are particularly interested in identifying novel secreted parasite effector proteins and in defining their mode of action. The project is likely to directly advance the goal of validating new essential and parasite-specific targets, and this will support future efforts to develop new Theileria treatments. The obtained results may also yield mechanistic insights that could be useful in the search for novel strategies in cancer therapy.

We are looking for a highly motivated student with a strong interest in cell biology to join our group. Experience in molecular biology and biochemistry is an advantage. The position requires a degree in biology, (veterinary) medicine, biochemistry or a related field. Fluent spoken and written English are prerequisites for this position.

We offer a young and enthusiastic research group, an inspiring research environment, state-of-the art research facilities at the attractive working location in Bern. The remuneration is in accordance with the Swiss National Science Foundation (SNF) regulations. The PhD student will be enrolled in the Graduate School of Cellular and Biomedical Sciences ( at the University of Bern.

The position is available as of March 1st, 2018 or by agreement.

How to apply: Please send your application, which should include a motivation letter, CV and references by email to: Ms. Christine Herzig ( Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann. ). For questions regarding the project please contact Dr. Philipp Olias ( Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann. ).

Zuletzt aktualisiert am Donnerstag, den 22. Februar 2018 um 11:33 Uhr