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Darmstadt University of Technology
Molecular Genetics


Postdoctoral Research Position

A postdoctoral position is available at the Darmstadt University of Technology in the laboratory of Prof. HU Göringer (Molecular Genetics, Department of Biology). We are seeking a highly motivated candidate with a research background in RNA (bio)chemistry including RNA structure probing techniques, UV-melting curve measurements and the biophysical characterization of RNA/protein interactions. Candidates should hold a PhD in Biochemistry, Chemistry or Biology.
The position is financed through the DFG-collaborative research center CRC902: Molecular principles of RNA-based regulation. The project is focused on RNA-driven genetic processes in African trypanosomes with a special emphasis on the U-nucleotide-specific RNA editing reaction of mitochondrial transcripts.
The Darmstadt University of Technology is an equity employer and encourages applications from women and persons with disabilities. Disabled people with the same qualifications will be given priority.


To apply, please send a cover letter and CV including the names of 3 references to Prof. Dr. HU Göringer at Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann. .

Additional information:

www.sfb902.de/home - project B3

www.tu-darmstadt.de/karriere_planen/allgemeineausschreibung/stellen_details_242752.de.jsp www.bio.tu-darmstadt.de/ag/professuren/goringer/Goeringer.en.jsp

 


 

PhD position in molecular parasitology at the Robert Koch Institute in Berlin

(as part of the International Research Training Program (IRTG 2290) "Crossing boundaries - molecular interactions in malaria")

Malaria, caused by the intracellular parasite Plasmodium spp., kills more than 400,000 people each year, and international efforts are ongoing to understand the biology of the pathogen and find new treatment options. Within the newly established DFG-funded International Research Training Program 2290 “Crossing boundaries - molecular interactions in malaria” (https://www.allianceberlincanberra.org/) a PhD position for 3 years is available at the Robert Koch Institute in Berlin (www.rki.de).

Your profile

You should ideally have a profound theoretical as well as experimental background in molecular techniques like DNA cloning, library constructions, cell transfections and/or protein analysis techniques. Substantial interests in biochemical questions paired with a strong ambition for innovative ideas are perfect matches to make this interesting project a success.

Proficiency in English is mandatory since the research project will involve work carried out in both Berlin and Canberra, with a one year stay in the partner labs at the Australian National University (ANU). PhD students will graduate with a dual PhD from both the Humboldt University and ANU. PhD students in the program will have the opportunity to participate in a customized training program that includes voluntary internships and that will supports students in acquiring critical skills to prepare for increasingly globalized and competitive public and private job markets.

Description of the project

The apicoplast is an essential plastid-like organelle of Plasmodium spp. and the related Toxoplasma gondii parasite. Its ferredoxin (Fd) redox system plays a central metabolic role as electron donor to enzymes via protein-protein interactions (PPI). The aim of the project is to study Fd’s PPIs to dissect its metabolic roles in the apicoplast and to elucidate in Plasmodium the role of reported Fd mutations in artemisinin resistance. These will be approached by genetic screens in E. coli for PPI inhibitors (i.e. cyclic peptide ‘dissociators’; Curr. Opin. Chem. Biol. 38, 30–35 (2017)) and their subsequent biophysical and in situ validation in the parasite on Fd’s function. These studies will be complemented with Fd gene knock-out in Plasmodium and assessment of artemisinin resistance with complemented mutants. For more information visit https://www.allianceberlincanberra.org/application-1/project-seeber/.

Application

Details for application can be found at https://www.allianceberlincanberra.org/application-1/general-information/. Note that for applying to this particular project (B6) the deadline has been extended to August 13th 2017. Start of the position is mid September 2017.

Contact

Prof. Dr. Frank Seeber

Robert Koch Institut - FG16 Parasitologie

Seestr. 10

D-13353 Berlin

Germany

email: Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann.

Zuletzt aktualisiert am Donnerstag, den 21. September 2017 um 10:05 Uhr